By E. Grundmann (auth.), E. Grundmann, H. Grunze, S. Witte (eds.)
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Eder:, M. : Morphological and autoradiographical investigations on experimental carcinogenesis and polyp development in the intestinal tract of rats and mice. Virchows Arch. A, 360, 179-193 (1973). 33 Discussions by Invitation Malignant Degeneration of Gastric Polyps? KEister Patholog. Institut der Stadt Krankenanstalten, Bayreuth Differentiation of gastric polyps based on biopsy specimens is not only problematic, but virtually impossible. The adenomatous polyp often shows a surface structure which corresponds to that of the hyperplastic polyp (SEIFERT and ELSTER, 1972).
However, this finding was not confirmed in a more resent study by STALSBERG and TAKSDAL (1971) who, in a necropsy series, were unable to find any difference in the inCidence of gastric cancer between the two groups: further data is therefore needed on this point. Fig. 5. Method of sectiuning a stomach and mapping out a surface carcinoma. (Reproduced by kind permission of the Editor of GUT) The relationship between atrophic gastritis and carcinoma is not clear: in this series atrophic gastritis has so far always been found in stomachs in which there is a surface carcinoma, usually but not always accompanied by intestinal metaplasia.
3) Comparable findings in human patients with polypous neoformations are, in the early phases, known as borderline types or, later, as polypous carcinomas. In the other case - with loss of the formation of contacts - separation from the epithelial complex and invasion of the stroma is effected, frequently in parallel with the property of monocellular mucilaginisation. Tl],e occurrence of both may happen in more or' less pure form and thereby determine formal genesis. Observations of early alterations in experimental animals, but also in man (NAGAYO et al.