By H. Jick (auth.), E. Grundmann (eds.)
Read or Download Drug-Induced Pathology PDF
Similar pathology books
The part on mobilephone biology has been vastly extended and now contains info on either the structural and sensible points of the subject.
Many malignant tumors have a morphologically recognizable precursor lesion. As screening and early detection have more advantageous our skill to notice lesions at more and more past phases of progress, an elevated variety of precancerous lesions are noticeable by way of pathologists. regrettably, a scarcity of uniform histologic standards for precursors present in many organs could make diagnostic interpretation tough.
Morson and Dawson’s Gastrointestinal Pathology5th EditionEdited by means of Neil A. Shepherd, DM, FRCPath, Gloucestershire mobile Pathology Laboratory, Cheltenham, united kingdom; Bryan F. Warren, MB, ChB, FRCP (London), FRCPath, John Radcliffe medical institution, Oxford, united kingdom; Geraint T. Williams, OBE, BSc, MD, MRCR, FRCP (London), FRCPath, FMedSci, Cardiff collage, Cardiff, united kingdom; Joel ok.
Extra resources for Drug-Induced Pathology
The development of de- 46 pendence and the appearance of withdrawal symptoms can be explained often on the basis of modified post-synaptic sensitivity not adequately compensated by pre-synaptic sensitivity. The recent discovery of enkephalin receptors on catecholaminergic nerve endings in the CNS may greatly contribute to an improved understanding of the mechanisms involved in the manifestations of the narcotic abstinence syndrome. Schwartz and associates (1978) have proposed that tolerance and dependence to opi ate drugs develop as a consequence of post-synaptic super sensitivity secondary to presynaptic inhibition of transmitter (including catecholamines) release in different area of the brain.
Disturbances of sex hormone metabolism High incidence of impotence, loss of libido and reduced fertility in drug-treated epileptic patients. Enhanced biodegradation cholecalciferol to inactive metabolites. of androgen steroids. metabolism. Induction of the biotransformation of these compounds is probably responsible for certain aspects of the chronic toxicity of antiepileptic drugs (Table 5) (Perucca 1978). In some cases enzyme-induction results in enhancement of the pharmacological effect, due to increased rate of formation of active metabolites.
Patients sensitive to the taste of quinine developed extrapyramidal signs at an average cumulative dose of prochlorperazine significantly lower than that required to produce the same effects in non-sensitive tasters (97 versus 225 mg respectively). Although no attempt was made to ascertain possible differences in drug disposition between the two groups, these and other fmdings by the same authors (Fischer et al. 1965) were interpreted as indicative of a relationship between drug responses at different sites of action.