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By H. J. Maurer, W. Clauss, T. Gulbrandsen, P. Dawson (auth.), Dr. Peter Dawson, Dr. Wolfram Clauß (eds.)

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Invest Radiol 23: S88-S89 3. Knoefel PK, Huang KC (1956) The biochemorphology of renal tubular transport: iodinated benzoic acids. J Pharm Exp Ther 117:307-316 4. Mitchell DG, Friedman AC (1985) Viscosity of iodinated contrast agents: significance for peripheral venous injection. J Comput Tomogr 9:77-78 5. Morris TW, Kern MA, Katzberg RW (1982) The effects of media viscosity on hemodynamics in selective arteriography. Invest Radio117:70-76 6. Morris TW, Sahler LG, Fischer HW (1982) Calcium binding by radiopaque media.

General Fundamentals 39. Muller N et al (1991) Results of a comparative pulmonary tolerance study in the dog following a single intrapulmonal application of three iodine-containing X-ray contrast media (lsovist-300, Ultravist-300, Angiografin). (in press) 40. Pasaouglu A et al (1988) An experimental evaluation of response to contrast media. Pantopaque, iopamidol, and iohexol in the subarachnoid space. Invest Radiol 23:762-766 41. Poggel HA (1984) Reproduktionstoxikologische Untersuchungen. 6, 4.

They proved to be reversible in additional studies performed on rats after repeated intravenous administration, the time needed for the changes to reverse depending upon the size of the selected dose and the frequency of administration. The pathogenesis of vacuolation of the proximal renal tubular epithelial cells is not as yet clear. Two possibilities are conceivable: 1. Iodinated X-ray eM are excreted by glomeruli. When administered in very high doses, small amounts can also be excreted by tubules but the Xray eM taken up from the blood by the tubular cells can only be reexcreted very slowly.

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