By Dennis Krikler (auth.), Professor Dr. M. Schlepper, Dr. B. Olsson (eds.)
Asked to arrange a world assembly on Propafenone (Ryt monorm) we needed to query ourselves, no matter if to simply accept this supply simply as physicians or in our ability as chairmen of the research team on arrhythmias and intracardiac electrography of the ecu Society of Cardiology. Considerung the "pros and contras" and good conscious that you can simply be considered as "product promoter" we, however, decide to arrange the Symposion in organization with the learn team. We felt justified to take action for a few purposes: Arrhyth mias and their remedy in addition to the instruments to realize the 1st and to manage the latter are good in the scope of the learn workforce. a global symposion supplied the chance to have the "state of the artwork" in arrhythmias and antiarrhythmic remedy completely reviewed by means of the world over popular investigators, hence serving an academic objective. in addition it was once the purpose and target of the assembly to have what's recognized a couple of really new drug provided in a severe demeanour and to indicate what's now not identified, yet could be identified. it's in that context the shows of the unfastened consultation will be judged. To the cautious reader it is going to develop into obvious that a lot which used to be no longer acknowledged, will be learn "between the lines".
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Extra info for Cardiac Arrhythmias: Diagnosis Prognosis Therapy
Ventricular Arrhythmias A total of 29 cases covered the entire spectrum of either common or rare ventricular tachyarrhythmias, which can be separated into categories (Table 2). , ~isopyramide Aprindine . Q~e Ajmaline Pmdolol - = - ...... .. J...... ••••• _••• Amiodarone Amiodarone Ajmaline 200mg 400mg ...... -- ............... _......... ~9'!! 360mg 600mg' Quiniduru le 19 SOOmg 19 NadolollSOmg - - - ~99,~9. 1979 F M A M A s o S o Q,dur. _ H H 1980 J F H M J J A H ......... Amiodarone r'I', ••' .
Sinus Rate, PR Interval and QRS Width The sinus frequency could be studied over a 24-h period, with and without P treatment, in only ten patients (nos. 2,8, 19, 22, 23, 25, 26, 32, 33, 35 and 45). The arrhythmias in the untreated patients were so frequent and so severe that accurate evaluation of the basic sinus rate on a statistical basis was not possible from the Holter recordings. 01). 02) while the night frequency evaluated 31 Efficacy of Oral Propafenone Table 3. 05). 1), was absolutely unchanged by P, confirming that the beta-inhibitory effect of the drug is comparable to that of amiodarone, but quite different from that of beta-blockers (Leclercq et al.
9. The first group was formed of P. -F. -. p Q • B B A Q Q + + A Fig. 9. Effects of single and combined therapies in ventricular tachycardias. Propafenone (P), quinidine (Q), beta-blockers (B) and amiodarone (A) were given alone in two groups often and nine patients respectively, followed by the combination of Q and B, or A and Q according to the resistance shown to single therapies. The mean results± SD were graded from 1 (no effect) to 5 (complete control). It is clear that propafenone results more or less surpass those of the other treatments, in patients who have been chosen specifically because of the resistance of their tachyarrhythmias ten patients (nos.