By Barbara J. Bain, David M. Clark, Irvin A. Lampert, Bridget S. Wilkins
Written by way of one of many world's major haematologists, and 3 well known histopathologists, Bone Marrow Pathology presents a accomplished consultant to the prognosis of bone marrow affliction. Now in its 3rd version, the textual content has been largely revised and rewritten to mirror the newest advances within the box.
An super useful, up to date textual content incorporating the recent WHO category of haematopoietic malignancies
A complete textual content written with nice precision and readability of style
Incorporates a brand new part 'Problems and Pitfalls' - a special part that may relief the operating pathologist confronted with a tricky situation
An very important textual content for the haematologist, histopathologist and haematopathologist with equivalent weight given to peripheral blood, aspirate, trephine biology and really good techniques
Extensively illustrated with a few of the pictures being of paraffin-embedded sections
Combines all of the options now utilized to bone marrow prognosis, together with immunocytochemistry, movement cytometery, immunohistochemistry and the diagnostic position of cytogenetic and molecular genetic analysis
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Additional info for Bone Marrow Pathology (3rd Edition)
Increased numbers of macrophages, including foamy macrophages, can be found. The scars of previous biopsies are usually apparent and repeat biopsies should be carried out from the other side of the pelvis or a centimetre or so away from any recent biopsy on the same side. It should also be noted that, if the pelvis has previously been irradiated, biopsies will show bone marrow hypoplasia or aplasia which is not indicative of the appearance of the bone marrow at other sites. Biopsy of previously irradiated bone marrow should therefore generally be avoided.
73) can result in a biopsy specimen showing a scar which, in the case of a previous trephine biopsy, may be linear. Scars should not be confused with ﬁbrosis resulting from other pathological processes. THE NORMAL BONE MARROW 49 (a) Fig. 73 Section of BM trephine biopsy specimen from an intravenous drug abuser with Hodgkin’s disease showing bone marrow scar; there is deposition of haemosiderin in the scar: (a) H&E ×376; (b) Perls’ stain ×376. References 1 Hashimoto M (1962) Pathology of bone marrow.
Semin Hematol, 18, 179–193. 3 Wickramasinghe SN. Human Bone Marrow. Blackwell Scientiﬁc Publications, Oxford, 1975. 4 Bennike T, Gormsen H and Moller B (1956) Comparative studies of bone marrow punctures of the sternum, the iliac crest, and the spinous process. Acta Med Scand, 155, 377–396. 5 Humphries J (1990) Dry tap bone marrow aspiration: clinical signiﬁcance. Am J Hematol, 35, 247–250. (b) 6 Aboul-Nasr R, Estey EH, Kantarjian HM, Freireich EJ, Andreeff M, Johnson BJ and Albitar M (1999) Comparison of touch imprints with aspirate smears for evaluating bone marrow specimens.