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Extra info for Biochemistry, Pathology and Genetics of Pulmonary Emphysema. Proceedings of an International Symposium Held in Sassari, Italy, 27–30 April 1980

Example text

Les cinq autres fractions contiennent des peptides p l u s polaires avec d e s m o s i n e et i s o d e s m o s i n e . S e u l s les peptides polaires c o n t e n a n t d e la d e s m o sine et d e l'isodesmosine sont antigéniques q u a n d ils sont titrés par i m m u n o d i f f u s i o n d o u b l e . L a séparation de ces fractions peptidiques antigéniques par électrophorèse sur gel d e P o l y acrylamide et de d o d é c y l sulphate de s o d i u m d o n n e trois bandes bien séparées au p o i d s m o l é c u l a i r e apparent de 6 4 0 0 0 , 55 0 0 0 et 14 0 0 0 daltons.

S o , w e also n e e d a m e t h o d w h i c h w o u l d detect the rather less specific s e q u e n c e s w h i c h m a y c o m e about without desmosine being touched. KUHN. — Before developing the R I A , GOLDSTEIN and STARCHER ( / . clin. , 1978, 61, 1 2 8 6 ) measured urinary d e s m o s i n e b y an a m i n o acid analyzer in the experimental m o d e l o f elastase induced e m p h y s e m a , a n d f o u n d , that w h e n o n e floods the lung with e x o g e n o u s elastase a n d destroys lots o f elastin, d e s m o s i n e d o e s appear in t h e urine.

KUHN and SENIOR [ 9 ] have discussed the advantages of using urinary desmosine as a measure of elastin turnover. These authors point out that desmosine is not absorbed from the intestine [ 1 4 ] , so that there is no dietary contribution to urinary desmosine levels. All desmosine excretion appears to be via the urine, they say, and there is no reutilization of desmosine. Thus, urinary desmosine could give a direct quantitative measure of endogenous elastin breakdown (although it would not tell from what tissue the desmosine is derived).

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